The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer
Homologous recombination (HR) is the main way to repair DNA double-stranded breaks, single-stranded DNA gaps and stagnation or folding replication forks, helping to maintain telomeres and ensure the correct segregation of chromosomes during meiosis. Homologous recombination repair (HRR) pathway is o...
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| Format: | Article |
| Language: | English |
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Editorial Office of China Oncology
2021-04-01
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| Series: | Zhongguo aizheng zazhi |
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| Online Access: | http://www.china-oncology.com/fileup/1007-3639/PDF/20210415.pdf |
| _version_ | 1811198047927926784 |
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| author | YU Li , SHEN Minna , JIANG Huiqin , WANG Beili , GUO Wei |
| author_facet | YU Li , SHEN Minna , JIANG Huiqin , WANG Beili , GUO Wei |
| author_sort | YU Li , SHEN Minna , JIANG Huiqin , WANG Beili , GUO Wei |
| collection | DOAJ |
| description | Homologous recombination (HR) is the main way to repair DNA double-stranded breaks, single-stranded DNA gaps and stagnation or folding replication forks, helping to maintain telomeres and ensure the correct segregation of chromosomes during meiosis. Homologous recombination repair (HRR) pathway is one of the DNA damage repair pathways, which has a high mutation frequency in cancers. Besides BRCA1/2 mutations, homologous recombination deficiency (HRD) can also be caused by other mechanisms, such as germline mutations, somatic mutations, genome stability of HRR-related genes and epigenetic modification of HRR genes. The latest clinical data show that reflecting HRD status through HRR gene mutations detection and genomic scar detection can effectively predict the efficiency of poly (ADP-ribose) polymerase inhibitor (PARPi) in patients with cancer and help patients to accurately use drugs and predict the prognosis. However, there are a variety of methods to identify HRD in cancers, the purpose of this paper was to summarize the detection methods of homologous recombination, to explore the value of HRD detection in clinical application, and to lay a foundation for precise treatment of cancer. |
| first_indexed | 2024-04-12T01:24:26Z |
| format | Article |
| id | doaj.art-a11f692dbb804c64be0c5ef3d5ef9155 |
| institution | Directory Open Access Journal |
| issn | 1007-3639 |
| language | English |
| last_indexed | 2024-04-12T01:24:26Z |
| publishDate | 2021-04-01 |
| publisher | Editorial Office of China Oncology |
| record_format | Article |
| series | Zhongguo aizheng zazhi |
| spelling | doaj.art-a11f692dbb804c64be0c5ef3d5ef91552022-12-22T03:53:42ZengEditorial Office of China OncologyZhongguo aizheng zazhi1007-36392021-04-0131434434910.19401/j.cnki.1007-3639.2021.04.015The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancerYU Li , SHEN Minna , JIANG Huiqin , WANG Beili , GUO Wei01. Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China; 2. Department of Laboratory Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen 361015, Fujian Province, ChinaHomologous recombination (HR) is the main way to repair DNA double-stranded breaks, single-stranded DNA gaps and stagnation or folding replication forks, helping to maintain telomeres and ensure the correct segregation of chromosomes during meiosis. Homologous recombination repair (HRR) pathway is one of the DNA damage repair pathways, which has a high mutation frequency in cancers. Besides BRCA1/2 mutations, homologous recombination deficiency (HRD) can also be caused by other mechanisms, such as germline mutations, somatic mutations, genome stability of HRR-related genes and epigenetic modification of HRR genes. The latest clinical data show that reflecting HRD status through HRR gene mutations detection and genomic scar detection can effectively predict the efficiency of poly (ADP-ribose) polymerase inhibitor (PARPi) in patients with cancer and help patients to accurately use drugs and predict the prognosis. However, there are a variety of methods to identify HRD in cancers, the purpose of this paper was to summarize the detection methods of homologous recombination, to explore the value of HRD detection in clinical application, and to lay a foundation for precise treatment of cancer.http://www.china-oncology.com/fileup/1007-3639/PDF/20210415.pdfcancer| homologous recombination deficiency| poly (adp-ribose) polymerase inhibitor|precision therapy |
| spellingShingle | YU Li , SHEN Minna , JIANG Huiqin , WANG Beili , GUO Wei The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer Zhongguo aizheng zazhi cancer| homologous recombination deficiency| poly (adp-ribose) polymerase inhibitor|precision therapy |
| title | The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer |
| title_full | The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer |
| title_fullStr | The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer |
| title_full_unstemmed | The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer |
| title_short | The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer |
| title_sort | progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer |
| topic | cancer| homologous recombination deficiency| poly (adp-ribose) polymerase inhibitor|precision therapy |
| url | http://www.china-oncology.com/fileup/1007-3639/PDF/20210415.pdf |
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