PRDM1 Drives Human Primary T Cell Hyporesponsiveness by Altering the T Cell Transcriptome and Epigenome

PRDM1 Drives Human Primary T Cell Hyporesponsiveness by Altering the T Cell Transcriptome and Epigenome

T cell hyporesponsiveness is crucial for the functional immune system and prevents the damage induced by alloreactive T cells in autoimmune pathology and transplantation. Here, we found low expression of PRDM1 in T cells from donor and recipients both related to the occurrence of acute graft-versus-...

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Bibliographic Details
Main Authors: Huidong Guo, Ming Wang, Bixia Wang, Liping Guo, Yifei Cheng, Zhidong Wang, Yu-Qian Sun, Yu Wang, Ying-Jun Chang, Xiao-Jun Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
PRDM1
multiomics
T cell hyporesponsiveness
HSCT
GvHD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.879501/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.879501/full

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