HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo.

HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo.

Recently, it was found that 80% of sexual HIV-1 transmissions are established by a single virion/viral genome. To investigate whether the transmitted/founder (T/F) viruses have specific biological properties favoring sexual transmission, we inoculated human cervical tissue explants with isogenic HIV...

Full description

Bibliographic Details
Main Authors: Melanie Merbah, Anush Arakelyan, Tara Edmonds, Christina Ochsenbauer, John C Kappes, Robin J Shattock, Jean-Charles Grivel, Leonid B Margolis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3516523?pdf=render

Internet

http://europepmc.org/articles/PMC3516523?pdf=render

Similar Items