Rare Variants in <i>LRP4</i> Are Associated with Mesiodens, Root Maldevelopment, and Oral Exostoses in Humans

Rare Variants in <i>LRP4</i> Are Associated with Mesiodens, Root Maldevelopment, and Oral Exostoses in Humans

Background: Low density lipoprotein receptor-related protein 4 (LRP4; MIM 604270) modulates WNT/β-catenin signaling, through its binding of WNT ligands, and to co-receptors LRP5/6, and WNT inhibitors DKK1, SOSTDC1, and SOST. LRP4 binds to SOSTDC1 and WNT proteins establishing a negative feedback loo...

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Bibliographic Details
Main Authors: Piranit Nik Kantaputra, Peeranat Jatooratthawichot, Ploy Adisornkanj, Panita Kitsadayurach, Massupa Kaewgahya, Bjorn Olsen, Atsushi Ohazama, Chumpol Ngamphiw, Sissades Tongsima, Timothy C. Cox, James R. Ketudat Cairns
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biology
Subjects:
root malformations
torus palatinus
torus mandibularis
buccal exostoses
root anomalies
Online Access:https://www.mdpi.com/2079-7737/12/2/220

Internet

https://www.mdpi.com/2079-7737/12/2/220

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