Dapagliflozin Promotes Neovascularization by Improving Paracrine Function of Skeletal Muscle Cells in Diabetic Hindlimb Ischemia Mice Through PHD2/HIF-1α Axis

Dapagliflozin Promotes Neovascularization by Improving Paracrine Function of Skeletal Muscle Cells in Diabetic Hindlimb Ischemia Mice Through PHD2/HIF-1α Axis

Diabetes mellitus is associated with a high risk of hindlimb ischemia (HLI) progression and an inevitably poor prognosis, including worse limb salvage and mortality. Skeletal muscle cells can secrete angiogenic factors, which could promote neovascularization and blood perfusion recovery. Thus, parac...

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Bibliographic Details
Main Authors: Dyah Ari Nugrahaningrum, Olivia Marcelina, Caiping Liu, Shourong Wu, Vivi Kasim
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
diabetic HLI
dapagliflozin
skeletal muscle cells
neovascularization
therapeutic angiogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01104/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01104/full

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