Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro[S]

Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro[S]

Haloperidol, a typical antipsychotic, has been shown to inhibit cholesterol biosynthesis by affecting Δ7-reductase, Δ8,7-isomerase, and Δ14-reductase activities, which results in the accumulation of different sterol intermediates. In the present work, we investigated the effects of atypical or secon...

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Bibliographic Details
Main Authors: Alberto Canfrán-Duque, María E. Casado, Óscar Pastor, Jana Sánchez-Wandelmer, Gema de la Peña, Milagros Lerma, Paloma Mariscal, Franz Bracher, Miguel A. Lasunción, Rebeca Busto
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Journal of Lipid Research
Subjects:
second-generation antipsychotic drugs
cholesterol biosynthesis
lipid synthesis
apolipoprotein B secretion
intracellular lipid traffic
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752042797X

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http://www.sciencedirect.com/science/article/pii/S002222752042797X

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