Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway

Protective Effects of 6-Gingerol on Cardiotoxicity Induced by Arsenic Trioxide Through AMPK/SIRT1/PGC-1α Signaling Pathway

Background and Objective: Arsenic trioxide (As2O3) induced cardiotoxicity to limit the clinical applications of the effective anticancer agent. 6-Gingerol (6G) is the main active ingredient of ginger, a food with many health benefits. The present study aims to investigate the potential pharmacologic...

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Bibliographic Details
Main Authors: Xue Han, Yakun Yang, Muqing Zhang, Xi Chu, Bin Zheng, Chenxu Liu, Yucong Xue, Shengjiang Guan, Shijiang Sun, Qingzhong Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
AMPK/SIRT1/PGC-1α pathway
arsenic trioxide
cardiotoxicity
6-gingerol
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.868393/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.868393/full

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