Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines

Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines

The prohibitin (PHB)-binding compound fluorizoline as well as PHB-downregulation activate the integrated stress response (ISR) in HEK293T and U2OS human cell lines. This activation is denoted by phosphorylation of eIF2α and increases in ATF4, ATF3, and CHOP protein levels. The blockage of the activa...

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Bibliographic Details
Main Authors: José Saura-Esteller, Ismael Sánchez-Vera, Sonia Núñez-Vázquez, Ana M. Cosialls, Pau Gama-Pérez, Gauri Bhosale, Lorena Mendive-Tapia, Rodolfo Lavilla, Gabriel Pons, Pablo M. Garcia-Roves, Michael R. Duchen, Daniel Iglesias-Serret, Joan Gil
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
fluorizoline
prohibitin
apoptosis
ISR
ER stress
Online Access:https://www.mdpi.com/1422-0067/22/11/6117

Internet

https://www.mdpi.com/1422-0067/22/11/6117

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