Gabapentin Disrupts Binding of Perlecan to the α<sub>2</sub>δ<sub>1</sub> Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation

Gabapentin Disrupts Binding of Perlecan to the α<sub>2</sub>δ<sub>1</sub> Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation

Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning the pericellular space of osteocytes and transmitting mechanical information into biochemical signals. While we identi...

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Bibliographic Details
Main Authors: Perla C. Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson, Xin Yi, Tristen V. Tellman, Andrei Bonteanu, Katie Rust, Megan L. Noonan, Kenneth E. White, Karl J. Lewis, Uma Sankar, Julia M. Hum, Gregory Bix, Danielle Wu, Alexander G. Robling, Rajesh Sardar, Mary C. Farach-Carson, William R. Thompson
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
perlecan
voltage-sensitive calcium channels
α<sub>2</sub>δ<sub>1</sub>
gabapentin
mechanosensation
bone
Online Access:https://www.mdpi.com/2218-273X/12/12/1857

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https://www.mdpi.com/2218-273X/12/12/1857

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