Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The Supe...

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Bibliographic Details
Main Authors: Daisy X Ji, Kristen C Witt, Dmitri I Kotov, Shally R Margolis, Alexander Louie, Victoria Chevée, Katherine J Chen, Moritz M Gaidt, Harmandeep S Dhaliwal, Angus Y Lee, Stephen L Nishimura, Dario S Zamboni, Igor Kramnik, Daniel A Portnoy, K Heran Darwin, Russell E Vance
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
mycobacterium tuberculosis
legionella pneumophila
type i interferon
Online Access:https://elifesciences.org/articles/67290

Internet

https://elifesciences.org/articles/67290

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