Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure

Deletion of the Cardiomyocyte Glucocorticoid Receptor Leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure

Background The contribution of glucocorticoids to sexual dimorphism in the heart is essentially unknown. Therefore, we sought to determine the sexually dimorphic actions of glucocorticoid signaling in cardiac function and gene expression. To accomplish this goal, we conducted studies on mice lacking...

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Bibliographic Details
Main Authors: Diana Cruz‐Topete, Robert H. Oakley, Natalie G. Carroll, Bo He, Page H. Myers, Xiaojiang Xu, Megan N. Watts, Krystle Trosclair, Edward Glasscock, Paari Dominic, John A. Cidlowski
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiomyocyte
glucocorticoid
glucocorticoid receptor
heart failure
sex hormones
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.011012

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.011012

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