Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis

Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis

Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption that may be therapeutically targetable. Among them, glucose metabolism and glycolytic intermediaries seem to have an important role in fibroblast-like synoviocytes (FLS) phenotype and might contribute to...

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Bibliographic Details
Main Authors: Patricia Gnieslaw de Oliveira, Mirian Farinon, Elsa Sanchez-Lopez, Shigeki Miyamoto, Monica Guma
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
fibroblast-like synoviocytes
hexokinase-2
glucose metabolism
glycolytic inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01743/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01743/full

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