Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants
Yang et al. report a mechanism of restoration of tumor suppressor activity of mutant p53 by disrupting its binding to peptidase D, leading to posttranslational modification, refolding and reactivation of the protein and its inhibition of cancer cell growth in vivo and in vitro. This finding presents...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02880-x |