Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants
Yang et al. report a mechanism of restoration of tumor suppressor activity of mutant p53 by disrupting its binding to peptidase D, leading to posttranslational modification, refolding and reactivation of the protein and its inhibition of cancer cell growth in vivo and in vitro. This finding presents...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02880-x |
| _version_ | 1828956063296126976 |
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| author | Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang |
| author_facet | Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang |
| author_sort | Lu Yang |
| collection | DOAJ |
| description | Yang et al. report a mechanism of restoration of tumor suppressor activity of mutant p53 by disrupting its binding to peptidase D, leading to posttranslational modification, refolding and reactivation of the protein and its inhibition of cancer cell growth in vivo and in vitro. This finding presents a new possibility of “reactivating” mutant p53 and reveals a new therapeutic approach for a large number of human tumors. |
| first_indexed | 2024-12-14T08:04:37Z |
| format | Article |
| id | doaj.art-a13fdeb0ff664f5d9b3080c20a5a80c4 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T08:04:37Z |
| publishDate | 2021-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a13fdeb0ff664f5d9b3080c20a5a80c42022-12-21T23:10:16ZengNature PortfolioCommunications Biology2399-36422021-12-014111610.1038/s42003-021-02880-xLoss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutantsLu Yang0Yun Li1Arup Bhattacharya2Yuesheng Zhang3Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer CenterDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer CenterDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer CenterDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer CenterYang et al. report a mechanism of restoration of tumor suppressor activity of mutant p53 by disrupting its binding to peptidase D, leading to posttranslational modification, refolding and reactivation of the protein and its inhibition of cancer cell growth in vivo and in vitro. This finding presents a new possibility of “reactivating” mutant p53 and reveals a new therapeutic approach for a large number of human tumors.https://doi.org/10.1038/s42003-021-02880-x |
| spellingShingle | Lu Yang Yun Li Arup Bhattacharya Yuesheng Zhang Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants Communications Biology |
| title | Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants |
| title_full | Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants |
| title_fullStr | Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants |
| title_full_unstemmed | Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants |
| title_short | Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants |
| title_sort | loss of peptidase d binding restores the tumor suppressor functions of oncogenic p53 mutants |
| url | https://doi.org/10.1038/s42003-021-02880-x |
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