A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling
Abstract Neudesin, originally identified as a neurotrophic factor, has primarily been studied for its neural functions despite its widespread expression. Using 8-week-old neudesin knockout mice, we elucidated the role of neudesin in the spleen. The absence of neudesin caused mild splenomegaly, short...
Main Authors: | Yoshiaki Nakayama, Yuki Masuda, Takehiro Mukae, Tadahisa Mikami, Ryohei Shimizu, Naoto Kondo, Hiroshi Kitagawa, Nobuyuki Itoh, Morichika Konishi |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-01-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-024-05802-9 |
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