Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies

Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies

Rhesus macaques (Macaca mulatta) are used as a human-relevant animal species for the evaluation of vaccines and as a source for cloning monoclonal antibodies (mAbs) that are highly similar to human-derived antibodies. Although antibody-secreting plasmablasts in humans are well-defined and can be eas...

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Bibliographic Details
Main Authors: Fan Zhang, Longyu Wang, Xuefeng Niu, Jiashun Li, Jia Luo, Yupeng Feng, Yanjia Yang, Ping He, Wenxia Fan, Renshan Liang, Zhiqiang Zheng, Weiqi Pan, Chufang Li, Yee Joo Tan, Haijian Yu, Ling Chen, Pingchao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
plasmablast
B cell
Chinese rhesus macaques
monoclonal antibodies
influenza virus
vaccination
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02426/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02426/full

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