MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions

MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions

Abstract DNA loop extrusion emerges as a key process establishing genome structure and function. We introduce MoDLE, a computational tool for fast, stochastic modeling of molecular contacts from DNA loop extrusion capable of simulating realistic contact patterns genome wide in a few minutes. MoDLE a...

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Bibliographic Details
Main Authors: Roberto Rossini, Vipin Kumar, Anthony Mathelier, Torbjørn Rognes, Jonas Paulsen
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Genome Biology
Subjects:
Loop extrusion
Stochastic modeling
Hi-C
Micro-C
TAD
Online Access:https://doi.org/10.1186/s13059-022-02815-7

Internet

https://doi.org/10.1186/s13059-022-02815-7

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