Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes

Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes

In the present study, we synthesized and, structurally and functionally characterized a novel α4/7-conotoxin Mr1.7 (PECCTHPACHVSHPELC-NH2), which was previously identified by cDNA libraries from Conus marmoreus in our lab. The NMR solution structure showed that Mr1.7 contained a 310-helix from resid...

Full description

Bibliographic Details
Main Authors: Shuo Wang, Cong Zhao, Zhuguo Liu, Xuesong Wang, Na Liu, Weihong Du, Qiuyun Dai
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Marine Drugs
Subjects:
neuronal nicotinic acetylcholine receptor
α-conotoxin Mr1.7
Conus marmoreus
selectivity
N-terminal sequence
structure-activity relationship
Online Access:http://www.mdpi.com/1660-3397/13/6/3259

Internet

http://www.mdpi.com/1660-3397/13/6/3259

Similar Items