Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics

Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics

Mutations within the <i>Leucine-Rich Repeat Kinase 2 (LRRK2)</i> gene are the most common genetic cause of autosomal and sporadic Parkinson’s disease (PD). LRRK2 is a large multidomain kinase that has reported interactions with several membrane proteins, including Rab and Endophilin, and...

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Bibliographic Details
Main Authors: Bethany J. Sanstrum, Brandee M. S. S. Goo, Diana Z. Y. Holden, Donovan D. Delgado, Thien P. N. Nguyen, Kiana D. Lee, Nicholas G. James
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
Parkinson’s disease
LRRK2
endocytosis
FLIM
FRET-Phasor
fluorescence fluctuation spectroscopy
Online Access:https://www.mdpi.com/1420-3049/25/11/2561

Internet

https://www.mdpi.com/1420-3049/25/11/2561

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