Plasma Gelsolin Confers Chemoresistance in Ovarian Cancer by Resetting the Relative Abundance and Function of Macrophage Subtypes

Plasma Gelsolin Confers Chemoresistance in Ovarian Cancer by Resetting the Relative Abundance and Function of Macrophage Subtypes

Ovarian cancer (OVCA) is the most lethal gynaecological cancer with a 5-year survival rate less than 50%. Despite new therapeutic strategies, such as immune checkpoint blockers (ICBs), tumor recurrence and drug resistance remain key obstacles in achieving long-term therapeutic success. Therefore, th...

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Bibliographic Details
Main Authors: Meshach Asare-Werehene, Hideaki Tsuyoshi, Huilin Zhang, Reza Salehi, Chia-Yu Chang, Euridice Carmona, Clifford L. Librach, Anne-Marie Mes-Masson, Chia-Ching Chang, Dylan Burger, Yoshio Yoshida, Benjamin K. Tsang
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
tumor-associated macrophages (TAMs)
plasma gelsolin (pGSN)
ovarian cancer (OVCA)
small extracellular vesicles (sEV)
chemoresistance
Online Access:https://www.mdpi.com/2072-6694/14/4/1039

Internet

https://www.mdpi.com/2072-6694/14/4/1039

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