EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

Abstract β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and release insulin. In type 1 diabetes (T1D), T-cells of the immune system selectively destroy the insulin-producing β-cells. Destruction of these cells leads to a lifelong dependence on exogenous insuli...

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Bibliographic Details
Main Authors: Keith Al-Hasani, Safiya Naina Marikar, Harikrishnan Kaipananickal, Scott Maxwell, Jun Okabe, Ishant Khurana, Thomas Karagiannis, Julia J. Liang, Lina Mariana, Thomas Loudovaris, Thomas Kay, Assam El-Osta
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01707-x

Internet

https://doi.org/10.1038/s41392-023-01707-x

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