Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration.

Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration.

The PALB2 tumor suppressor plays key roles in DNA repair and has been implicated in redox homeostasis. Autophagy maintains mitochondrial quality, mitigates oxidative stress and suppresses neurodegeneration. Here we show that Palb2 deletion in the mouse brain leads to mild motor deficits and that co-...

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Bibliographic Details
Main Authors: Yanying Huo, Akshada Sawant, Yongmei Tan, Amar H Mahdi, Tao Li, Hui Ma, Vrushank Bhatt, Run Yan, Jake Coleman, Cheryl F Dreyfus, Jessie Yanxiang Guo, M Maral Mouradian, Eileen White, Bing Xia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010138

Internet

https://doi.org/10.1371/journal.pgen.1010138

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