NGS allele counts versus called genotypes for testing genetic association

NGS allele counts versus called genotypes for testing genetic association

RNA sequence data are commonly summarized as read counts. By contrast, so far there is no alternative to genotype calling for investigating the relationship between genetic variants determined by next-generation sequencing (NGS) and a phenotype of interest. Here we propose and evaluate the direct an...

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Bibliographic Details
Main Authors: Rosa González Silos, Christine Fischer, Justo Lorenzo Bermejo
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Genotype calling
Next generation sequencing
Allele counts
Genetic association tests
Statistical power
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022002951

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http://www.sciencedirect.com/science/article/pii/S2001037022002951

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