Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning
The pregnane X receptor (PXR, <i>NR1I2</i>) is a nuclear receptor which exerts its regulatory function by heterodimerization with the retinoid-X-receptor α (RXRα, <i>NR2B1</i>) and binding to the promoter and enhancer regions of diverse target genes. PXR is involved in the re...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/11/3137 |