An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation

An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation

Ricin toxin, a plant-derived, mannosylated glycoprotein, elicits an incapacitating and potentially lethal inflammatory response in the airways following inhalation. Uptake of ricin by alveolar macrophages (AM) and other pulmonary cell types occurs via two parallel pathways: one mediated by ricin’s B...

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Bibliografische gegevens
Hoofdauteurs: Yinghui Rong, Fernando J. Torres-Velez, Dylan Ehrbar, Jennifer Doering, Renjie Song, Nicholas J. Mantis
Formaat: Artikel
Taal:English
Gepubliceerd in: Taylor & Francis Group 2020-04-01
Reeks:Human Vaccines & Immunotherapeutics
Onderwerpen:
toxin
lung
inflammation
antibody
biodefense
Online toegang:http://dx.doi.org/10.1080/21645515.2019.1664243

Internet

http://dx.doi.org/10.1080/21645515.2019.1664243

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