Tristetraprolin specifically regulates the expression and alternative splicing of immune response genes in HeLa cells

Tristetraprolin specifically regulates the expression and alternative splicing of immune response genes in HeLa cells

Abstract Background Tristetraprolin (TTP) is an RNA binding protein that plays a critical role in regulating proinflammatory immune responses by destabilizing target mRNAs via binding to their AU-rich elements (AREs) in the 3′-UTRs of mRNAs. A recent CLIP-seq study revealed that TTP-binding sites ar...

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Bibliographic Details
Main Authors: Yafang Tu, Xiongfei Wu, Fengyun Yu, Jianzhong Dang, Juan Wang, Yaxun Wei, Zhitao Cai, Zhipeng Zhou, Wenliang Liao, Lian Li, Yi Zhang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Immunology
Subjects:
ZFP36
Overexpression
RNA-seq
Gene expression
Alternative splicing
Online Access:http://link.springer.com/article/10.1186/s12865-019-0292-1

Internet

http://link.springer.com/article/10.1186/s12865-019-0292-1

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