Single-molecule imaging of microRNA-mediated gene silencing in cells

For decades, miRNAs have been studied primarily by ensemble methods, where a bulk collection of molecules is measured outside cells. Here, Kobayashi and Singer report methods to image miRNA function at the single-molecule level inside cells.

Bibliographic Details
Main Authors: Hotaka Kobayashi, Robert H. Singer
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29046-5