Calreticulin induces dilated cardiomyopathy.

Calreticulin induces dilated cardiomyopathy.

Calreticulin, a Ca(2+)-buffering chaperone of the endoplasmic reticulum, is highly expressed in the embryonic heart and is essential for cardiac development. After birth, the calreticulin gene is sharply down regulated in the heart, and thus, adult hearts have negligible levels of calreticulin. In t...

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Bibliographic Details
Main Authors: Dukgyu Lee, Tatsujiro Oka, Beth Hunter, Alison Robinson, Sylvia Papp, Kimitoshi Nakamura, Wattamon Srisakuldee, Barbara E Nickel, Peter E Light, Jason R B Dyck, Gary D Lopaschuk, Elissavet Kardami, Michal Opas, Marek Michalak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3577809?pdf=render

Internet

http://europepmc.org/articles/PMC3577809?pdf=render

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