FBXL4 deficiency increases mitochondrial removal by autophagy

FBXL4 deficiency increases mitochondrial removal by autophagy

Abstract Pathogenic variants in FBXL4 cause a severe encephalopathic syndrome associated with mtDNA depletion and deficient oxidative phosphorylation. To gain further insight into the enigmatic pathophysiology caused by FBXL4 deficiency, we generated homozygous Fbxl4 knockout mice and found that the...

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Bibliographic Details
Main Authors: David Alsina, Oleksandr Lytovchenko, Aleksandra Schab, Ilian Atanassov, Florian A Schober, Min Jiang, Camilla Koolmeister, Anna Wedell, Robert W Taylor, Anna Wredenberg, Nils‐Göran Larsson
Format: Article
Language:English
Published: Springer Nature 2020-06-01
Series:EMBO Molecular Medicine
Subjects:
autophagy
FBXL4
mitochondrial disease
mtDNA
oxidative phosphorylation
Online Access:https://doi.org/10.15252/emmm.201911659

Internet

https://doi.org/10.15252/emmm.201911659

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