Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis

Nlrp2 deletion ameliorates kidney damage in a mouse model of cystinosis

Cystinosis is a rare autosomal recessive disorder caused by mutations in the CTNS gene that encodes cystinosin, a ubiquitous lysosomal cystine/H+ antiporter. The hallmark of the disease is progressive accumulation of cystine and cystine crystals in virtually all tissues. At the kidney level, human c...

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Bibliographic Details
Main Authors: Marianna Nicoletta Rossi, Valentina Matteo, Francesca Diomedi-Camassei, Ester De Leo, Olivier Devuyst, Mohamed Lamkanfi, Ivan Caiello, Elena Loricchio, Francesco Bellomo, Anna Taranta, Francesco Emma, Fabrizio De Benedetti, Giusi Prencipe
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
cystinosis
inflammation
fibrosis
NLRP2
chronic kidney disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1373224/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1373224/full

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