Ivabradine Hydrochloride (S)-Mandelic Acid Co-Crystal: In Situ Preparation during Formulation

Ivabradine Hydrochloride (S)-Mandelic Acid Co-Crystal: In Situ Preparation during Formulation

The pharmaceutical salt ivabradine hydrochloride is indicated for the symptomatic treatment of chronic stable angina pectoris and chronic heart failure. It exhibits extensive polymorphism and co-crystallization, which could be a way to provide an alternative solid form. We conducted a co-crystal scr...

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Bibliographic Details
Main Authors: Veronika Sládková, Ondřej Dammer, Gregor Sedmak, Eliška Skořepová, Bohumil Kratochvíl
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Crystals
Subjects:
co-crystals
crystal polymorphism
crystal structure
preformulation
X-ray powder diffractometry
Online Access:http://www.mdpi.com/2073-4352/7/1/13

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http://www.mdpi.com/2073-4352/7/1/13

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