Spatially Resolved Proteomic and Transcriptomic Profiling of Anaplastic Lymphoma Kinase-Rearranged Pulmonary Adenocarcinomas Reveals Key Players in Inter- and Intratumoral Heterogeneity

Spatially Resolved Proteomic and Transcriptomic Profiling of Anaplastic Lymphoma Kinase-Rearranged Pulmonary Adenocarcinomas Reveals Key Players in Inter- and Intratumoral Heterogeneity

Pulmonary adenocarcinomas (pADCs) with an <i>ALK</i> rearrangement are a rare cancer subtype, necessitating comprehensive molecular investigations to unravel their heterogeneity and improve therapeutic strategies. In this pilot study, we employed spatial transcriptomic (NanoString GeoMx)...

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Bibliographic Details
Main Authors: Beáta Szeitz, Tibor Glasz, Zoltán Herold, Gábor Tóth, Mirjam Balbisi, János Fillinger, Szabolcs Horváth, Réka Mohácsi, Ho Jeong Kwon, Judit Moldvay, Lilla Turiák, Attila Marcell Szász
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
lung adenocarcinoma
pulmonary adenocarcinoma
<i>ALK</i> rearrangement
multi-omics
digital spatial profiling
proteomics
Online Access:https://www.mdpi.com/1422-0067/24/14/11369

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https://www.mdpi.com/1422-0067/24/14/11369

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