Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats

Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats

The present study tested the hypothesis that thrombin participates in formation of left atrial remodeling and that direct oral anticoagulants, such as direct thrombin inhibitors (DTIs), can prevent its progression. In a rat model of heart failure associated with left atrial dilation, we found that c...

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Bibliographic Details
Main Authors: Céline Jumeau, PharmD, PhD, Alain Rupin, PharmD, PhD, Pauline Chieng-Yane, PhD, Nathalie Mougenot, PhD, Noël Zahr, PharmD, PhD, Monique David-Dufilho, PhD, Stéphane N. Hatem, MD, PhD
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:JACC: Basic to Translational Science
Subjects:
anticoagulant
atrial arrhythmia
direct thrombin inhibitor
heart failure
remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16300304

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http://www.sciencedirect.com/science/article/pii/S2452302X16300304

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