Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
The present study tested the hypothesis that thrombin participates in formation of left atrial remodeling and that direct oral anticoagulants, such as direct thrombin inhibitors (DTIs), can prevent its progression. In a rat model of heart failure associated with left atrial dilation, we found that c...
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Format: | Article |
Language: | English |
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Elsevier
2016-08-01
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Series: | JACC: Basic to Translational Science |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X16300304 |
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author | Céline Jumeau, PharmD, PhD Alain Rupin, PharmD, PhD Pauline Chieng-Yane, PhD Nathalie Mougenot, PhD Noël Zahr, PharmD, PhD Monique David-Dufilho, PhD Stéphane N. Hatem, MD, PhD |
author_facet | Céline Jumeau, PharmD, PhD Alain Rupin, PharmD, PhD Pauline Chieng-Yane, PhD Nathalie Mougenot, PhD Noël Zahr, PharmD, PhD Monique David-Dufilho, PhD Stéphane N. Hatem, MD, PhD |
author_sort | Céline Jumeau, PharmD, PhD |
collection | DOAJ |
description | The present study tested the hypothesis that thrombin participates in formation of left atrial remodeling and that direct oral anticoagulants, such as direct thrombin inhibitors (DTIs), can prevent its progression. In a rat model of heart failure associated with left atrial dilation, we found that chronic treatment with DTIs reduces the atrial remodeling and the duration of atrial fibrillation (AF) episodes induced by burst pacing by inhibiting myocardial hypertrophy and fibrosis. In addition to the prevention of thromboembolism complicating AF, DTIs may be of interest to slow down the progression of the arrhythmogenic substrate. |
first_indexed | 2024-12-16T14:37:36Z |
format | Article |
id | doaj.art-a16b4b40cac9415bb9982ec12e6fab0b |
institution | Directory Open Access Journal |
issn | 2452-302X |
language | English |
last_indexed | 2024-12-16T14:37:36Z |
publishDate | 2016-08-01 |
publisher | Elsevier |
record_format | Article |
series | JACC: Basic to Translational Science |
spelling | doaj.art-a16b4b40cac9415bb9982ec12e6fab0b2022-12-21T22:28:03ZengElsevierJACC: Basic to Translational Science2452-302X2016-08-011532833910.1016/j.jacbts.2016.05.002Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in RatsCéline Jumeau, PharmD, PhD0Alain Rupin, PharmD, PhD1Pauline Chieng-Yane, PhD2Nathalie Mougenot, PhD3Noël Zahr, PharmD, PhD4Monique David-Dufilho, PhD5Stéphane N. Hatem, MD, PhD6Sorbonne University, Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherche 1166, Institute of Cardiometabolism and Nutrition (ICAN), Paris, FranceServier Research Institute, Suresnes, FranceFRS Consulting, Paris, FranceInserm-Sorbonnes-Universités, Unité Mixte de Service 28 Université Pierre et Marie Curie, Paris, FranceINSERM Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière Department of Pharmacology and Centre d'Investigation Clinique 1421, Paris, FranceSorbonne University, Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherche 1166, Institute of Cardiometabolism and Nutrition (ICAN), Paris, FranceSorbonne University, Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherche 1166, Institute of Cardiometabolism and Nutrition (ICAN), Paris, FranceThe present study tested the hypothesis that thrombin participates in formation of left atrial remodeling and that direct oral anticoagulants, such as direct thrombin inhibitors (DTIs), can prevent its progression. In a rat model of heart failure associated with left atrial dilation, we found that chronic treatment with DTIs reduces the atrial remodeling and the duration of atrial fibrillation (AF) episodes induced by burst pacing by inhibiting myocardial hypertrophy and fibrosis. In addition to the prevention of thromboembolism complicating AF, DTIs may be of interest to slow down the progression of the arrhythmogenic substrate.http://www.sciencedirect.com/science/article/pii/S2452302X16300304anticoagulantatrial arrhythmiadirect thrombin inhibitorheart failureremodeling |
spellingShingle | Céline Jumeau, PharmD, PhD Alain Rupin, PharmD, PhD Pauline Chieng-Yane, PhD Nathalie Mougenot, PhD Noël Zahr, PharmD, PhD Monique David-Dufilho, PhD Stéphane N. Hatem, MD, PhD Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats JACC: Basic to Translational Science anticoagulant atrial arrhythmia direct thrombin inhibitor heart failure remodeling |
title | Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats |
title_full | Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats |
title_fullStr | Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats |
title_full_unstemmed | Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats |
title_short | Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats |
title_sort | direct thrombin inhibitors prevent left atrial remodeling associated with heart failure in rats |
topic | anticoagulant atrial arrhythmia direct thrombin inhibitor heart failure remodeling |
url | http://www.sciencedirect.com/science/article/pii/S2452302X16300304 |
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