Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension
Cells in a tumor microenvironment are exposed to spatial and temporal variations in oxygen tension due to hyperproliferation and immature vascularization. Such spatiotemporal oxygen heterogeneity affects the behavior of cancer cells, leading to cancer growth and metastasis, and thus, it is essential...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2020-03-01
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| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/1.5127069 |