High throughput human genotyping for variants associated with malarial disease outcomes using custom targeted amplicon sequencing

Abstract Malaria has exhibited the strongest known selective pressure on the human genome in recent history and is the evolutionary driving force behind genetic conditions, such as sickle-cell disease, glucose-6-phosphatase deficiency, and some other erythrocyte defects. Genomic studies (e.g., The 1...

Full description

Bibliographic Details
Main Authors: Ashley Osborne, Jody E. Phelan, Leen N. Vanheer, Alphaxard Manjurano, Jesse Gitaka, Christopher J. Drakeley, Akira Kaneko, Kiyoshi Kita, Susana Campino, Taane G. Clark
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-39233-z