IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3

IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3

Abstract Background Although interferon regulatory factor 2 (IRF2) was reported to stimulate virus replication by suppressing the type I interferon signaling pathway, because cell cycle arrest was found to promote viral replication, IRF2-regulated replication fork factor (FAM111A and RFC3) might be...

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Bibliographic Details
Main Authors: Kai Ren, Ya Zhu, Honggang Sun, Shilin Li, Xiaoqiong Duan, Shuang Li, Yujia Li, Bin Li, Limin Chen
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Virology Journal
Subjects:
ZIKV
IRF2
Jak/STAT signaling pathways
FAM111A
RFC3
Online Access:https://doi.org/10.1186/s12985-021-01724-8

Internet

https://doi.org/10.1186/s12985-021-01724-8

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