Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies

Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies

The enzyme reverse transcriptase (RT) plays a central role in the life cycle of human immunodeficiency virus (HIV), and RT has been an important drug target. Elucidations of the RT structures trapping and detailing the enzyme at various functional and conformational states by X-ray crystallography h...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Abhimanyu K. Singh, Kalyan Das
פורמט:	Article
שפה:	English
יצא לאור:	MDPI AG 2022-05-01
סדרה:	Viruses
נושאים:	HIV-RT NRTI NNRTI drug design structural biology crystallography
גישה מקוונת:	https://www.mdpi.com/1999-4915/14/5/1027

פריטים דומים

Approved HIV reverse transcriptase inhibitors in the past decade
מאת: Guangdi Li, et al.
יצא לאור: (2022-04-01)

Mathematical Modelling of the Molecular Mechanisms of Interaction of Tenofovir with Emtricitabine against HIV
מאת: Sara Iannuzzi, et al.
יצא לאור: (2021-07-01)

The “Connection” Between HIV Drug Resistance and RNase H
מאת: Krista A. Delviks-Frankenberry, et al.
יצא לאור: (2010-07-01)

Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz + tenofovir + emtricitabine for HIV
מאת: Oliver T. Stirrup, et al.
יצא לאור: (2019-10-01)

Development of HIV Drug Resistance in a Cohort of Adults on First-Line Antiretroviral Therapy in Tanzania during the Stavudine Era
מאת: Raphael Z. Sangeda, et al.
יצא לאור: (2021-11-01)

Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase
מאת: Elleder Daniel, et al.
יצא לאור: (2012-12-01)

Efficacy and safety of novel russian non-nucleoside reverse transcriptase inhibitor elsulfavirine in combination with 2 nucleoside/nucleotide reverse transcriptase inhibitors in first-line HIV treatment – 96-week study
מאת: A. V. Kravchenko, et al.
יצא לאור: (2018-07-01)

Diaryl ethers with carboxymethoxyphenacyl motif as potent HIV-1 reverse transcriptase inhibitors with improved solubility
מאת: Tomasz Frączek, et al.
יצא לאור: (2018-01-01)

APOBEC3 selects V179I in HIV-1 reverse transcriptase to provide selective advantage for non-nucleoside reverse transcriptase inhibitor-resistant mutants
מאת: Richa Dwivedi, et al.
יצא לאור: (2022-07-01)

Incidence and risk factors for neuropsychiatric events among Ghanaian HIV patients on long-term non-nucleoside reverse transcriptase inhibitor-based therapy
מאת: Fred S. Sarfo, et al.
יצא לאור: (2016-06-01)

Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors
מאת: Nicolas Sluis-Cremer, et al.
יצא לאור: (2013-11-01)

Chronic Hepatitis B Treatment Strategies Using Polymerase Inhibitor-Based Combination Therapy
מאת: Eriko Ohsaki, et al.
יצא לאור: (2021-08-01)

Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability
מאת: Ya-Li Sang, et al.
יצא לאור: (2023-07-01)

The long-term outcomes of antiretroviral treatment initiated with mono or dual nucleoside reverse transcriptase inhibitors in HIV-1-infected children: an Asian observational study
מאת: Orasri Wittawatmongkol, et al.
יצא לאור: (2015-07-01)

Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability
מאת: Xin Jin, et al.
יצא לאור: (2023-03-01)

Thymidine Analogue Mutations with M184V Significantly Decrease Phenotypic Susceptibility of HIV-1 Subtype C Reverse Transcriptase to Islatravir
מאת: Hyeonah Byun, et al.
יצא לאור: (2024-12-01)

Anti‐HIV drugs reduce risk of prediabetes and progression to type 2 diabetes in HIV‐infected patients
מאת: Joseph Magagnoli, et al.
יצא לאור: (2023-06-01)

Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs
מאת: Ting-Ting Li, et al.
יצא לאור: (2020-03-01)

Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport
מאת: John Haynes, et al.
יצא לאור: (2024-12-01)

The Lysine 65 Residue in HIV-1 Reverse Transcriptase Function and in Nucleoside Analog Drug Resistance
מאת: Scott J. Garforth, et al.
יצא לאור: (2014-10-01)

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase
מאת: Stefan G. Sarafianos, et al.
יצא לאור: (2010-02-01)

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
מאת: Kamalendra Singh, et al.
יצא לאור: (2014-09-01)

Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data
מאת: Oliver T. Stirrup, et al.
יצא לאור: (2018-04-01)

Evaluation of the HIV-1 drug resistance to elsulfavirine and the effectiveness of it among Russian treatment-naïve patients
מאת: A. A. Kirichenko, et al.
יצא לאור: (2021-01-01)

Global Conformational Dynamics of HIV-1 Reverse Transcriptase Bound to Non-Nucleoside Inhibitors
מאת: Peter V. Coveney, et al.
יצא לאור: (2012-07-01)

Drosophila model of anti-retroviral therapy induced peripheral neuropathy and nociceptive hypersensitivity
מאת: Keegan M. Bush, et al.
יצא לאור: (2021-01-01)

Nucleoside Analog 2′,3′-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1
מאת: Ksenia Glumakova, et al.
יצא לאור: (2023-09-01)

NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal
מאת: Benjamin Trinité, et al.
יצא לאור: (2019-06-01)

HIV drug resistance prediction with weighted categorical kernel functions
מאת: Elies Ramon, et al.
יצא לאור: (2019-07-01)

HIV medication to prevent fetal infection during pregnancy
מאת: Teodora Gabriela Cioroba, et al.
יצא לאור: (2022-03-01)

High frequency of Lamivudine and Telbivudine resistance mutations in hepatitis B virus isolates from human immunodeficiency virus co-infected patients on highly active antiretroviral therapy in Bucaramanga, Colombia
מאת: Henry Bautista-Amorocho, et al.
יצא לאור: (2023-07-01)

Anthrarufin and Its Anionic Moieties as Potential Inhibitors of HIV-1 Reverse Transcriptase (RT)
מאת: Svetlana Jeremić, et al.
יצא לאור: (2022-11-01)

K103N, V106M and Y188L Significantly Reduce HIV-1 Subtype C Phenotypic Susceptibility to Doravirine
מאת: Nikita Reddy, et al.
יצא לאור: (2024-09-01)

Virulence and Replicative Fitness of HIV-1 Transmitted/Founder (T/F) Viruses Harbouring Drug Resistance-Associated Mutation
מאת: Aanand Sonawane, et al.
יצא לאור: (2024-11-01)

Machine learning aided multiscale modelling of the HIV-1 infection in the presence of NRTI therapy
מאת: Huseyin Tunc, et al.
יצא לאור: (2023-03-01)

Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase
מאת: Thomas W. Kirby, et al.
יצא לאור: (2023-11-01)

The Molecular Docking of Specific Reverse Transcriptase Inhibitory Ligands onto the Molecular Model of HIV-1 Reverse Transcriptase
מאת: Roohallah Yousefi
יצא לאור: (2024-06-01)

Virtual screening, molecular docking studies and DFT calculations of FDA approved compounds similar to the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz
מאת: Maryam A. Jordaan, et al.
יצא לאור: (2020-08-01)

Structure-Based Discovery and Characterization of a Preclinical Drug Candidate for the Treatment of HIV-1 Infection
מאת: Dongwei Kang, et al.
יצא לאור: (2022-10-01)

Transmitted drug resistance to rilpivirine among antiretroviral‐naïve patients living with HIV from northern Poland
מאת: Miłosz Parczewski, et al.
יצא לאור: (2014-01-01)