CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients

CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients

Abstract Neutrophils have a pathogenic function in inflammation via releasing pro-inflammatory mediators or neutrophil extracellular traps (NETs). However, their heterogeneity and pro-inflammatory mechanisms remain unclear. Here, we demonstrate that CXCR4hi neutrophils accumulate in the blood and in...

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Bibliographic Details
Main Authors: Jiaoling Chen, Yaxing Bai, Ke Xue, Zhiguo Li, Zhenlai Zhu, Qingyang Li, Chen Yu, Bing Li, Shengxian Shen, Pei Qiao, Caixia Li, Yixin Luo, Hongjiang Qiao, Erle Dang, Wen Yin, Johann E. Gudjonsson, Gang Wang, Shuai Shao
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41484-3

Internet

https://doi.org/10.1038/s41467-023-41484-3

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