Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells
Abstract Background The safety of CRISPR-based gene editing methods is of the utmost priority in clinical applications. Previous studies have reported that Cas9 cleavage induced frequent aneuploidy in primary human T cells, but whether cleavage-mediated editing of base editors would generate off-tar...
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | लेख |
| भाषा: | English |
| प्रकाशित: |
BMC
2024-11-01
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| श्रृंखला: | Genome Biology |
| विषय: | |
| ऑनलाइन पहुंच: | https://doi.org/10.1186/s13059-024-03434-0 |