Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

Islet-enriched transcription factors (TFs) exert broad control over cellular processes in pancreatic α and β cells, and changes in their expression are associated with developmental state and diabetes. However, the implications of heterogeneity in TF expression across islet cell populations are not...

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Bibliographic Details
Main Authors: Shristi Shrestha, Diane C. Saunders, John T. Walker, Joan Camunas-Soler, Xiao-Qing Dai, Rachana Haliyur, Radhika Aramandla, Greg Poffenberger, Nripesh Prasad, Rita Bottino, Roland Stein, Jean-Philippe Cartailler, Stephen C.J. Parker, Patrick E. MacDonald, Shawn E. Levy, Alvin C. Powers, Marcela Brissova
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-09-01
Series:JCI Insight
Subjects:
Cell biology
Endocrinology
Online Access:https://doi.org/10.1172/jci.insight.151621

Internet

https://doi.org/10.1172/jci.insight.151621

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