Spatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cells.

Spatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cells.

Canonical WNT/β-catenin signaling is a central pathway in embryonic development, but it is also connected to a number of cancers and developmental disorders. Here we apply a combined in-vitro and in-silico approach to investigate the spatio-temporal regulation of WNT/β-catenin signaling during the e...

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Bibliographic Details
Main Authors: Fiete Haack, Heiko Lemcke, Roland Ewald, Tareck Rharass, Adelinde M Uhrmacher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4368204?pdf=render

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http://europepmc.org/articles/PMC4368204?pdf=render

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