Comparative analysis of the neutralizing activity against SARS-CoV-2 Wuhan-Hu-1 strain and variants of concern: Performance evaluation of a pseudovirus-based neutralization assay

Comparative analysis of the neutralizing activity against SARS-CoV-2 Wuhan-Hu-1 strain and variants of concern: Performance evaluation of a pseudovirus-based neutralization assay

ObjectivesEmergence of new variants of SARS-CoV-2 might affect vaccine efficacy. Therefore, assessing the capacity of sera to neutralize variants of concern (VOCs) in BSL-2 conditions will help evaluating the immune status of population following vaccination or infection.MethodsPseudotyped viruses b...

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Bibliographic Details
Main Authors: Luciana D’Apice, Maria Trovato, Giulia Gramigna, Francesca Colavita, Massimo Francalancia, Giulia Matusali, Silvia Meschi, Daniele Lapa, Aurora Bettini, Klizia Mizzoni, Luigi Aurisicchio, Antonino Di Caro, Concetta Castilletti, Piergiuseppe De Berardinis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
COVID-19
SARS-CoV-2
variants of concern
pseudotyped virus
neutralization assay
neutralizing antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.981693/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.981693/full

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