The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation

In this work, the authors report that heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1 by inducing hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation.

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Markus Meier, Monika Gupta, Serife Akgül, Matthew McDougall, Thomas Imhof, Denise Nikodemus, Raphael Reuten, Aniel Moya-Torres, Vu To, Fraser Ferens, Fabian Heide, Gay Pauline Padilla-Meier, Philipp Kukura, Wenming Huang, Birgit Gerisch, Matthias Mörgelin, Kate Poole, Adam Antebi, Manuel Koch, Jörg Stetefeld
التنسيق: مقال
اللغة:English
منشور في: Nature Portfolio 2023-03-01
سلاسل:Nature Communications
الوصول للمادة أونلاين:https://doi.org/10.1038/s41467-023-36692-w