ECFC-derived exosomal THBS1 mediates angiogenesis and osteogenesis in distraction osteogenesis via the PI3K/AKT/ERK pathway

ECFC-derived exosomal THBS1 mediates angiogenesis and osteogenesis in distraction osteogenesis via the PI3K/AKT/ERK pathway

Background: Distraction osteogenesis (DO) is a widely used bone regenerative technique. However, the DO process is slow, and the consolidation phase is long. Therefore, it is of great clinical significance to explore the mechanism of DO, and shorten its duration. Recent studies reported that stem ce...

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Bibliographic Details
Main Authors: Fengchun Liao, Ziqi Liao, Tao Zhang, Weidong Jiang, Peiqi Zhu, Zhenchen Zhao, Henglei Shi, Dan Zhao, Nuo Zhou, Xuanping Huang
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Journal of Orthopaedic Translation
Subjects:
Endothelial colony-forming cell
Exosome
Distraction osteogenesis
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X22000808

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http://www.sciencedirect.com/science/article/pii/S2214031X22000808

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