Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

Summary: DNA methylation is a key regulator of gene expression and a clinical therapeutic predictor. We examined global DNA methylation beyond the generally used promoter areas in human small cell lung cancer (SCLC) and find that gene body methylation is a robust positive predictor of gene expressio...

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Bibliographic Details
Main Authors: Lorinc S. Pongor, Camille Tlemsani, Fathi Elloumi, Yasuhiro Arakawa, Ukhyun Jo, Jacob M. Gross, Sara Mosavarpour, Sudhir Varma, Rahul K. Kollipara, Nitin Roper, Beverly A. Teicher, Mirit I. Aladjem, William Reinhold, Anish Thomas, John D. Minna, Jane E. Johnson, Yves Pommier
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Epigenetics
Cancer systems biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222016108

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222016108

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