Carbonic anhydrase IX subcellular localization in normoxic and hypoxic SH-SY5Y neuroblastoma cells is assisted by its C-terminal protein interaction domain

Carbonic anhydrase IX subcellular localization in normoxic and hypoxic SH-SY5Y neuroblastoma cells is assisted by its C-terminal protein interaction domain

The human carbonic anhydrase IX (CA IX) is a hypoxia-induced transmembrane protein belonging to the α-CA enzyme family. It has a crucial role in pH regulation in hypoxic cells and acts by buffering intracellular acidosis induced by hypoxia. Indeed, it is frequently expressed in cancer cells, where i...

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Bibliographic Details
Main Authors: Mariangela Succoio, Sara Amiranda, Emanuele Sasso, Carmen Marciano, Arianna Finizio, Giuseppina De Simone, Corrado Garbi, Nicola Zambrano
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Heliyon
Subjects:
Hypoxia
NLS
Nuclear import
Carbonic anhydrase
Protein glycosylation
Membrane protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023060930

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http://www.sciencedirect.com/science/article/pii/S2405844023060930

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