IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response

IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response

IRE1α is one of the three ER transmembrane transducers of the Unfolded Protein Response (UPR) activated under endoplasmic reticulum (ER) stress. IRE1α activation has a dual role in cancer as it may be either pro- or anti-tumoral depending on the studied models. Here, we describe the discovery that e...

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Bibliographic Details
Main Authors: Adriana Martinez-Turtos, Rachel Paul, Manuel Grima-Reyes, Hussein Issaoui, Adrien Krug, Rana Mhaidly, Jozef P. Bossowski, Johanna Chiche, Sandrine Marchetti, Els Verhoeyen, Eric Chevet, Jean-Ehrland Ricci
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Cancer
UPR
IRE1α
XBP1s
RIDD
anti-cancer immunosurveillance
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2116844

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2116844

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