Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway

Abstract The activation of pancreatic stellate cells (PSCs) is the key mechanism of pancreatic fibrosis, which can lead to β-cell failure. Oxidative stress is an important risk factor for PSC activation. There is no direct evidence proving if administration of glutathione can inhibit fibrosis and β-...

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Bibliographic Details
Main Authors: Jitai Zhang, Juan Bai, Qian Zhou, Yuxin Hu, Qian Wang, Lanting Yang, Huamin Chen, Hui An, Chuanzan Zhou, Yongyu Wang, Xiufang Chen, Ming Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04894-7