RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely understood. Receptor interacting protein kinas...

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Bibliographic Details
Main Authors: Noyonika Mukherjee, Christopher J. Contreras, Li Lin, Kaitlyn A. Colglazier, Egan G. Mather, Michael A. Kalwat, Nathalie Esser, Steven E. Kahn, Andrew T. Templin
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Molecular Metabolism
Subjects:
RIPK3
Islet amyloid
β-cell cytotoxicity
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000085

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http://www.sciencedirect.com/science/article/pii/S2212877824000085

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